2021欧洲杯竞猜

揭示抑郁症患者脑中的“钝感世界”

浙大学者与加拿大渥太华大学教授合作揭示抑郁障碍的感知异常及脑分子机制

发布时间:2021-04-26来源:浙大新闻办作者:杨金98

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2021欧洲杯竞猜zheidagailvjiushiyiyuzhenghuanzheyanzhongdeshijie!

4月16日,欧洲杯竞猜app医学院系统神经与认知科学研究所的宋雪梅团队与浙大医学院附属精神卫生中心/杭州第七人民医院谭忠林团队,以及加拿大渥太华大学精神卫生研究所的Georg Northoff 教授合作,在国际著名期刊《Molecular Psychiatry》在线发表题为“Reduction of higher-order occipital GABA and impaired visual perception in acute major depressive disorder”的研究论文,揭示了抑郁患者的感知异常及其脑分子机制。


受困于“钝感世界”,抑郁患者感知功能异常

抑郁障碍通常被认为与情绪低落和记忆的认知损伤相关联,但往往忽视了很多抑郁患者可能正在以异常的方式感知着这个世界。

研究团队通过心理物理的实验方法检测抑郁患者的运动视觉感知能力,发现抑郁患者内在对外部世界运动的跟随能力与正常人相比更加缓慢。并且,抑郁患者外周抑制能力越弱,即识别外周差异的能力越弱,抑郁严重程度越重,即汉密顿抑郁评分越高。

实验中,受试者被要求判断移动光栅刺激的运动方向。抑郁患者与健康被试相比,需要更长的时间才能正确判断小光栅的运动方向,并且识别差异的外周抑制功能更弱。


感知测量范式(上)以及测量结果(下)


探知“钝感”来源,揭示脑分子机制

抑郁患者运动视觉感知异常来自哪里?

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抑郁障碍患者GABAGlutamate神经递质浓度明显降低

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超高场7T核磁氢谱成像技术直接探测中颞叶复合体脑区神经递质的绝对浓度

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主要研究者

世界一流超高场磁共振成像平台以及优秀的核磁技术团队

(文 杨金\图片来源于研究团队)



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